How the Keto Diet, Fasting, and DNP use Ketones to Accelerate Fat Loss, Lower Insulin Sensitivity, and Virtually Reverse Diabetes

When it comes to health trends, the ketosis diet and fasting are often the most cited when it comes to highly effective weight loss methods. While considered extreme by some, many scientific studies back the effectiveness of both approaches.  

With that being said, it may come as a surprise that fasting and the keto diet share several similarities with 2, 4 Dinitrophenol (DNP). The obvious parallel is that all three methods are highly useful tools for weight loss.  

The true similarity, however, lies within the fact that fasting, the ketosis diet, and DNP all cause the body to undergo ketosis.

Let’s take a closer look at each of these weight loss methods to gain a deeper understanding of how they relate to one another.


DNP is a chemical that’s highly effective at eating away excessive stores of fat while maintaining muscle mass. In fact, it’s likely the fastest method of losing weight when compared to fasting (both intermittent and prolonged) and the keto diet.

DNP lowers the rate that cellular mitochondria can produce ATP (the body’s primary usable energy source). This act, known as uncoupling of oxidative phosphorylation, is vital when it comes to burning fat quickly.

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Typically, when we eat food, it’s converted within the body into a form of usable energy (ATP). DNP interferes with this process by blocking the production of ATP by preventing the absorption of phosphate molecules into the mitochondria. In other words, this forces the body to work harder than average while producing less.

When DNP is in effect in your system, the energy you would typically absorb from calories will instead be expelled from your body in the form of heat. This is the reason why DNP users report sensations of overheating.

Just like fasting and the keto diet, DNP causes the body to undergo ketosis to induce fat loss. Due to the unique side effects of DNP limiting your carb intake, adopting a low-carb diet (such as the keto diet) should help reduce the sensation of overheating.

Over the years, DNP has struggled with a bad reputation. DNP was first labeled as “not for human consumption” by the Federal Food, Drug, and Cosmetic Act of 1938 due to several deaths linked to its usage.

Unfortunately, not much was known about DNP during that time period and a combination of bad marketing on the part of pharmaceutical companies and misuse by unknowing consumers caused many overdoses to occur.

Recently, DNP has been making a comeback online, but it still has a long way to go before more people accept it.

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Benefits of DNP

Despite the public stigma associated with DNP, it may have several benefits besides that of weight loss.

  1. May have positive benefits for diabetes  

Just like fasting and the keto diet, DNP may have the ability to improve sensitivity to insulin. This may be tied to the fact that DNP expels carbohydrates from the body in the form of heat though more research is needed.  Regardless, a study on a rat specimen showed an increase to insulin sensitivity.  


  1. May have a beneficial effect on age-related neurological disorders

Yet another similarity DNP shares with fasting and the keto diet is that it may have a positive impact on the brain. Specifically, neurological disorders such as Huntington’s Disease.

In addition, a study performed on a rat that suffered from an ischemic stroke showed that DNP reduced the overall adverse effects.

  1. May have a positive impact on liver disease

While deadly in itself, non-alcoholic fatty liver disease often lays the groundwork for various types of deadly disorders and diseases to take hold in the body. A study on a rat model found that DNP usage reduced liver lipids by up to 90%.

The common similarity shared between Fasting, the Keto diet, and DNP

While there are several similarities between fasting, the keto diet, and DNP the common denominator amongst all three is ketosis.

To reiterate, ketosis is a normal function in the body that occurs when there aren’t enough carbs in your system to burn for energy. It instead burns fat and produces a substance called ketones, which can be used as an alternative source of fuel.

A common question asked is whether or not ketosis is safe for the body. Simply put, the process of ketosis is generally normal and safe. The process to induce ketosis to occur, however, such as long-term fasting or taking too much DNP, can prove to be dangerous.

You should be well-informed about the method of weight-loss you decide to pursue to ensure you do so effectively and safely.

Intermittent Fasting

Intermittent fasting is a method of eating that focuses on cycling between restricting calories and eating as you usually would during a set period in time.

One of the most popular fasting routines is the Warrior Diet, a method of eating based on the eating habits of ancient warriors.

Another popular diet that relies heavily on intermittent fasting is the 16/8 method, which involves eating during a window of eight hours before fasting for the remaining 16 hours in the day.

Though weight loss is typically the driving force behind intermittent fasting, it also comes with a range of additional benefits.


Numerous studies show that when done correctly, intermittent fasting can have a powerfully positive impact on your body and brain. Here are a few of the most beneficial effects you’ll see to your health with intermittent fasting.

  1. Helps to reduce insulin resistance and can lower your risk of Type 2 Diabetes

According to the International Diabetes Federation, more than 400 million people worldwide currently live with diabetes. This can be primarily blamed on poor diet and exercise.

Type 2 Diabetes is characterized by high blood sugar levels in individuals who have built up a significant resistance to insulin.

Studies show that intermittent fasting may have positive benefits for insulin resistance and has the potential to decrease blood sugar levels significantly.

Another study performed on diabetic rats showed that intermittent fasting has the potential to protect against kidney damage. In yet another study conducted on humans, it was found that intermittent fasting reduced blood sugar levels by 3 – 6 %.

  1. May have benefits for heart health  

Heart disease is one of the biggest killers in the world, killing approximately 610,000 people in the United States each year alone. There are a variety of risk factors that can increase your chances of developing heart disease.

Several of these risk factors include blood pressure, blood triglycerides, LDL cholesterol, blood sugar levels, and inflammatory markers, to name a few. Various tests have shown that intermittent fasting has been known to improve many of these risk factors, in turn, reducing the chance of developing heart disease.

  1. Good for the brain

It’s important to ensure we’re healthy in both body and mind. Research shows that intermittent fasting is linked to improvements in a variety of metabolic features well known for being vitally important to the health of our brain.

These features include a reduction in insulin resistance, oxidative stress, and blood sugar levels. Studies performed on rat subjects found that intermittent fasting can be linked to the growth of new nerve cells, which should have a direct benefit on brain functionality.

Further animal studies have revealed that intermittent fasting may protect against brain damage that may be brought on by the effects of having a stroke.

What about prolonged fasting?

Prolonged fasting can be seen as one of the more extreme methods of losing weight, and comes in a variety of forms. The most extreme form is a “dry fast,” which involves not consuming anything at all (this includes water).

Dry fasting is generally inadvisable because you’re depriving your body of water. If you go without water for even a day, you may put yourself at significant risk.

There is also water fasting, which involves consuming only water during your fast but not consuming calories. Similar long-term fasting methods include broth fasting, juice fasting, and fasting with low-calorie protein mixes.

While prolonged fasting is riskier than intermittent fasting, it comes with its own set of benefits. For instance, the primary benefit is that you’ll lose weight faster because you’re not eating anything.

Your body will eat away at all of the glycogen in your liver within the first 24 hours. After this period, your body will begin to power itself by eating away the fat stored in your body.  

This is when ketosis takes place, producing a substance called ketones as you burn fat. Ketones are used as a form of “backup” energy when the body begins to starve. This may sound alarming, but ketones essentially serve to power your body when no other form of energy exists.

While potentially dangerous if done incorrectly, prolonged fasting has been known to promote autophagy, your body’s way of cleaning out damaged cells to recycle and replace them with clean, functional cells. Long-term fasting may also have potential benefits for chemotherapy and hypertension patients.

The most significant danger faced by those who rely upon long-term fasting is possible starvation. That said, it isn’t typical for those who use this method for medical reasons to take it to such extremes.

Regardless, it’s essential to know what can go wrong in a worst-case scenario. For instance, you should be aware that your body will eventually begin cannibalizing cardiac muscle for fuel.

While the body will attempt to preserve as much muscle as it can during the beginning of your fast, you may inevitably lose muscle mass. This is the case even if the process of ketosis has begun.

Some people who have engaged in long-term fasting have even died of infectious diseases that they’ve grown too weak to fight off due to lack of adequate nutrition. It turns out that the most common form of death that occurs amongst people who are starving isn’t lack of food, but sickness and disease.

An immune system weakened by malnutrition is often underequipped to deal with outside threats. As such, individuals who are starving are usually done in by external forces.

While there are many dangers associated with long-term fasting, it still shares many of the same benefits as intermittent fasting. Chief amongst these is the process of ketosis which promotes fast weight loss and provides your body with extra reserves of energy.

The Ketosis Diet

The ketosis diet, popularly known as the keto diet, focuses on consuming a high number of fats but reducing carbs.

In most instances’ carbs are reduced to about 50 grams per day, forcing your body to rely primarily on fats as opposed to glucose as its primary source of energy. The point of the keto diet is to induce the body to undergo ketosis.

The five variations of the keto diet

There are five variations of the ketosis diet which have all been scientifically proven to be beneficial to weight loss.  Each variation originated from the “classic ketogenic diet,” which was created by Dr. Russel Wilder at the Mayo Clinic in 1923, where it was used to treat epilepsy.

The classic ketogenic diet, or classic keto for short, carries a 4:1 ratio, meaning there is four parts fat for every one-part carbohydrate and protein.

Here’s a quick breakdown of each variation of the keto diet:   

Classic keto

6% protein / 4% carbs / 90% fat

An individualized and highly structured diet that relies upon a precise meal plan. These meals are weighed and should be entirely consumed to get the best results.

Modified keto

12% protein / 6% carbs / 82% Fat

Modifies the restrictiveness of the classic keto diet which can prove to be beneficial when first starting. Modified keto is also useful when building towards a more sustainable diet you intend on maintaining for the long-term.

Low glycemic index

30% protein/ 10% carb / 60% fat

While still individualized, this is a less structured diet. This variation uses exchange lists for planning out meals and puts a special emphasis on complex carbohydrates. This is not a plan that promotes ketosis.

Modified Atkins

30% protein / 5% carb / 65% fat

The modified Atkins diet encourages more fats, limits carb intake, but does not limit protein. When carbohydrates are consumed, they must be accompanied by fat.


10% protein / 17% carb / 73% fat

A highly structured and individualized diet that contains highly ketogenic Medium Chain Triglycerides (MCT). The main differentiator of this variation of the diet is that it allows for more carbs and protein than the classic keto diet.

Lifestyle changes

Ketogenic therapy focuses on more than just adjusting your diet. You must also increase electrolytes, hydration, and nutritional supplements. This can be difficult to juggle on your own without making a mistake. As a solution, many people turn to ketogenic specialists who can keep them on the right path to help them achieve success with their new shift in diet and lifestyle.

Benefits of the Keto diet

  1. Reduced blood sugar and insulin levels

Ketogenic diets can be especially helpful for people with insulin resistance and diabetes. Research shows that cutting down on carbohydrate intake can significantly lower insulin levels and blood sugar.

One particular study found that some diabetic test volunteers may have been able to reduce their dosage of insulin by 50% right away.

In another study that involved several test volunteers with Type 2 Diabetes, 95% of the study participants had either reduced or outright eliminated the medication they relied on to lower glucose.

  1. A viable treatment for several types of brain disorders

Glucose is a requirement for the brain to function correctly, as certain parts of the brain burns only this type of sugar. However, a sizable portion of the brain can also burn ketones. This is one of the primary reasons that ketogenic therapy is used to treat cases of epilepsy.

There have been several cases of children cured of epilepsy because they switched to the keto diet (or a similar low-carb diet). One study, in particular, found that over half of the children on the keto diet experienced a reduction of 50% or greater in the number of seizures they would generally suffer. An additional 16% became seizure-free altogether.

  1. Provides an effective defense against metabolic syndrome

Metabolic syndrome is made up of a variety of symptoms that include:

  • Elevated blood pressure

  • Low “good” HDL cholesterol levels

  • Abdominal obesity

  • Elevated fasting blood pressure

  • High triglycerides

Individuals who have this condition have an increased rate of diabetes and heart disease. Studies show, however, that adopting a low-carb diet can be an effective treatment option for all five of the aforementioned symptoms.

Side effects and signs of Ketosis

Following a week or so after going on a diet, or after you begin taking DNP, you may start to feel unwell. While this may be cause for concern in some instances, it may also be an indication of ketosis at work.

Some doctors believe this feeling may be a result of sugar and carbohydrate withdrawal, but there has yet to be evidence of this being the case. Other theories suggest that feelings of sickness may stem from a reaction from your immune system. It may also be linked to bacteria in your gut.

Common temporary side effects often include:

    • Sugar cravings

    • Nausea

    • Cramps

    • Bad breath

    • Sore muscles

    • Constipation

    • Brain fog

    • Dizziness

    • Irritability

    • Insomnia

Unofficially, these symptoms are called “keto flu.” That said, there has yet to be an official medical diagnose for these symptoms in relation to ketosis.

Testing your ketosis levels

If you’re curious about your ketosis levels, there are three testing methods you can use: breath, blood, and urine.

Numerous sites sell ketosis testing strips that you can have mailed to you so you can test your urine from home. Testing your breath for ketosis may have varying results, and is often more expensive than testing urine.

Testing your blood provides the most accurate results. It’s likely because of this fact that it’s generally the most expensive option.

Final Thoughts

Fasting, the keto diet, and DNP all rely upon ketosis to shed weight quickly from the body. You may be wondering if it’s safe to use these methods together. Done right, you should be able to perform the following pairings safely:

    • Keto diet with DNP

    • Fasting with DNP

    • Keto diet with intermittent fasting

While we can make recommendations, you should not take our word for medical law. Factors such as age, weight, and body type may affect the way you can safely employ the above methods to lose weight.

At Zeus DNP we produce only the highest-quality DNP capsules. Our capsules are produced in a safe environment, allowing us to focus on quality assurance to deliver a safe product to our customers.   

We seek to demystify DNP, so you can be confident in your decision in whether or not it’s right for you. If you’re in search of quality DNP, visit us today.

*DNP is not for human consumption



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